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ID: ALA1147479
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation.
Authors: Hong SY, Chung KH, You HJ, Choi IH, Chae MJ, Han JY, Jung OJ, Kang SJ, Ryu CK.
Abstract: A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
CiteXplore: 15177474