Document Report Card
Basic Information
ID: ALA1147491
Journal: Bioorg Med Chem Lett
Title: Complestatin synthetic studies; the effect of the amino acid configuration on peptide backbone conformation in the common western BCD macrocycle.
Authors: Smith AB, Chruma JJ, Han Q, Barbosa J.
Abstract: The synthesis and structural analysis, involving X-ray crystallographic, nuclear magnetic resonance, and computational studies of four diastereomers of the common western BCD diarylether macrocycle of the complestatins, a family of HIV entry inhibitors, has been achieved exploiting a ruthenium-promoted intramolecular S(N)Ar reaction. The stereogenicity of the individual phenylglycines (residues C and D) results in remarkable effects on the backbone conformation.
CiteXplore: 15026053