Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.

ID: ALA1147502

Journal: Bioorg Med Chem Lett

Title: Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.

Authors: Palani A, Dugar S, Clader JW, Greenlee WJ, Ruperto V, Duffy RA, Lachowicz JE.

Abstract: Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1.

CiteXplore: 15026073

DOI: 10.1016/j.bmcl.2004.01.033

Patent ID: ┄