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ID: ALA1147535
Journal: Bioorg Med Chem Lett
Title: Biaryl amide glucagon receptor antagonists.
Authors: Kurukulasuriya R, Sorensen BK, Link JT, Patel JR, Jae HS, Winn MX, Rohde JR, Grihalde ND, Lin CW, Ogiela CA, Adler AL, Collins CA.
Abstract: Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.
CiteXplore: 15080976