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ID: ALA1147539

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.

Authors: Akritopoulou-Zanze I, Patel JR, Hartandi K, Brenneman J, Winn M, Pratt JK, Grynfarb M, Goos-Nisson A, Von Geldern TW, Kym PR.

Abstract: We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.

CiteXplore: 15080982

DOI: 10.1016/j.bmcl.2004.02.048