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ID: ALA1147555
Journal: Bioorg Med Chem Lett
Title: 2,3-diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors.
Authors: Hyup Joo Y, Kwan Kim J, Kang SH, Noh MS, Ha JY, Kyu Choi J, Lim KM, Chung S.
Abstract: A new series of cyclooxygenase-2 (COX-2) inhibitors with gamma-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.
CiteXplore: 15081007