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ID: ALA1147557
Journal: Bioorg Med Chem Lett
Title: Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates.
Authors: Galan MC, Dodson CS, Venot AP, Boons GJ.
Abstract: A range of N-acetyllactosamine derivatives, which are modified by a wide range of functionalities at C-2(') and C-6, have been synthesised and the kinetic parameters of transfer catalysed by recombinant alpha-2,6-sialyltransferase and alpha-1,3-fucoyltransferase VI determined. Several of the chemical modifications led to selective modulate the activity the enzymes and offer promising lead compounds for the development of oligosaccharide primers for selective metabolic inhibition of oligosaccharide biosynthesis.
CiteXplore: 15081009