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ID: ALA1147561
Journal: Bioorg Med Chem Lett
Title: Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries.
Authors: Liu L, Ping Li C, Cochran S, Ferro V.
Abstract: A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either an aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.
CiteXplore: 15081013