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ID: ALA1147565
Journal: Bioorg Med Chem Lett
Title: Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors.
Authors: Byth KF, Culshaw JD, Green S, Oakes SE, Thomas AP.
Abstract: Exploration of SAR and optimisation of the imidazo[1,2-a]pyridine CDK inhibitors has lead to the discovery of novel, potent and selective inhibitors of the cyclin-dependent kinase CDK2. Understanding of SAR has identified positions of substitution, which allow modification of physical properties and offer the potential for in vivo optimisation.
CiteXplore: 15081017