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ID: ALA1147572
Journal: Bioorg Med Chem Lett
Title: Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta.
Authors: Gong B, Hong F, Kohm C, Jenkins S, Tulinsky J, Bhatt R, De Vries P, Singer JW, Klein P.
Abstract: 2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated.
CiteXplore: 15081029