Document Report Card
Basic Information
ID: ALA1147582
Journal: Bioorg Med Chem Lett
Title: Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin.
Authors: Lal B, Gund VG.
Abstract: Semisynthetic modifications at position-12 (ornithine-5-position, hemiaminal function) of mulundocandin were carried out to improve its chemical stability. New carbon-carbon (C-C) and carbon-hydrogen (C-H) linkage at hemiaminal function -12 has been achieved. Lewis acid catalyzed introduction of electron rich aryl group at position-12 of mulundocandin is developed. Synthesized mulundocandin analogues were evaluated for their chemical stability and antifungal activity against C. albicans and A. fumigatus.
CiteXplore: 14980649