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ID: ALA1147586
Journal: Bioorg Med Chem Lett
Title: Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.
Authors: Matthews JM, Liotta F, Hageman W, Rivero RA, Westover L, Yang M, Xu J, Demarest K.
Abstract: The use of a multiplex mimetic assay led us to identify 1,4-dihydropyrimidines with potent and selective calcitonin receptor mimetic activity. Subsequent modification of the dihydropyrimidine scaffold led to a series of molecules that were efficacious in a neonatal mouse calvaria in vitro model. Dihydropyrimidine 5h, in particular, was identified as a calcitonin mimetic (EC(50)=6 microM), active in-vivo in the Weanling rat model when administered subcutaneously.
CiteXplore: 14980655