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ID: ALA1147591
Journal: Bioorg Med Chem Lett
Title: A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives.
Authors: Kurata H, Suzuki S, Ohhata Y, Ikeda T, Hasegawa T, Kitayama K, Inaba T, Kono K, Kohama T.
Abstract: A series of 4-oxo-1-phenyl-1,4-dihydroquinolines possessing a linker and an ammonio moiety were synthesized and found to inhibit the apical sodium-dependent bile acid transporter (ASBT). The potency of ASBT inhibition varied with the position and length of the linking tether. Compound 21e effectively lowered the total serum cholesterol levels in hamsters.
CiteXplore: 14980661