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ID: ALA1147597
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluations of novel benzimidazoles as potential antibacterial agents.
Authors: He Y, Yang J, Wu B, Risen L, Swayze EE.
Abstract: A series of novel benzimidazole derivatives were synthesized via parallel solution-phase chemistry. Many of these compounds were found to inhibit the growth of Staphylococcus aureus and Escherichia coli. Several analogues exhibited low micromolar minimal inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria of clinical relevance and could serve as leads for further optimizations for antibacterial research.
CiteXplore: 14980669