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ID: ALA1147605
Journal: Bioorg Med Chem Lett
Title: Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine.
Authors: Choi DR, Shin JH, Yang J, Yoon SH, Jung YH.
Abstract: The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.
CiteXplore: 14980680