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ID: ALA1147607
Journal: Bioorg Med Chem Lett
Title: Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult.
Authors: Kim DS, Kim JY.
Abstract: Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.
CiteXplore: 14980683