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ID: ALA1147615
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of novel small molecule N/OFQ receptor antagonists.
Authors: Chen Z, Goehring RR, Valenzano KJ, Kyle DJ.
Abstract: Small molecule N/OFQ receptor antagonists were designed and synthesized to further investigate the therapeutic potential of N/OFQ receptor modulators. The resulting octahydrobenzimidazol-2-ones 14 and 23 show excellent antagonistic activity towards both N/OFQ and mu receptors with high affinity to the human N/OFQ receptor.
CiteXplore: 14980696