The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.
Basic Information
ID: ALA1147621
Journal: Bioorg Med Chem Lett
Title: The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.
Authors: Look GC, Vacin C, Dias TM, Ho S, Tran TH, Lee LL, Wiesner C, Fang F, Marra A, Westmacott D, Hromockyj AE, Murphy MM, Schullek JR.
Abstract: Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
CiteXplore: 15006375
DOI: 10.1016/j.bmcl.2004.01.026
Patent ID: ┄