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ID: ALA1147648

Journal: Bioorg Med Chem Lett

Title: Substituted coumarins as potent 5-lipoxygenase inhibitors.

Authors: Grimm EL, Brideau C, Chauret N, Chan CC, Delorme D, Ducharme Y, Ethier D, Falgueyret JP, Friesen RW, Guay J, Hamel P, Riendeau D, Soucy-Breau C, Tagari P, Girard Y.

Abstract: Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.

CiteXplore: 16464579

DOI: 10.1016/j.bmcl.2006.01.085