Document Report Card

ID: ALA1147654

Journal: J Med Chem

Title: Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.

Authors: Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP.

Abstract: We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the alpha4beta2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine.

CiteXplore: 16640326

DOI: 10.1021/jm051196m