Document Report Card
Basic Information
ID: ALA1147699
Journal: Bioorg Med Chem Lett
Title: Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues.
Authors: Dai GF, Xu HW, Wang JF, Liu FW, Liu HM.
Abstract: A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM. The structure-activity relationships were also discussed.
CiteXplore: 16504503