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ID: ALA1147702

Journal: Bioorg Med Chem Lett

Title: N-Benzylbenzamides: a new class of potent tyrosinase inhibitors.

Authors: Cho SJ, Roh JS, Sun WS, Kim SH, Park KD.

Abstract: A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC(50) of 2.2microM.

CiteXplore: 16513349

DOI: 10.1016/j.bmcl.2006.02.018