Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.

ID: ALA1147753

Journal: Bioorg Med Chem Lett

Title: Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.

Authors: Leban J, Kralik M, Mies J, Baumgartner R, Gassen M, Tasler S.

Abstract: A previously discovered DHODH inhibitor series was further improved by replacing the cyclopentene ring by aromatic heterocycles. Different isomers of these compounds were prepared by the directed ortho-metallation procedure. The compounds are more active than the corresponding cyclopentene analogs and show potent effects on PBMC's proliferation.

CiteXplore: 16246558

DOI: 10.1016/j.bmcl.2005.10.011

Patent ID: ┄