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ID: ALA1147762
Journal: Bioorg Med Chem Lett
Title: A new chemical tool for exploring the physiological function of the PDE2 isozyme.
Authors: Chambers RJ, Abrams K, Garceau NY, Kamath AV, Manley CM, Lilley SC, Otte DA, Scott DO, Sheils AL, Tess DA, Vellekoop AS, Zhang Y, Lam KT.
Abstract: Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
CiteXplore: 16275071