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ID: ALA1147770
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.
Authors: Strancar K, Blanot D, Gobec S.
Abstract: A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC(50) values near 100 microM and constitute a promising starting point for further development.
CiteXplore: 16271472