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ID: ALA1147770

Journal: Bioorg Med Chem Lett

Title: Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.

Authors: Strancar K, Blanot D, Gobec S.

Abstract: A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC(50) values near 100 microM and constitute a promising starting point for further development.

CiteXplore: 16271472

DOI: 10.1016/j.bmcl.2005.09.086