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ID: ALA1147773
Journal: Bioorg Med Chem Lett
Title: Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
Authors: Starck JP, Talaga P, Quéré L, Collart P, Christophe B, Lo Brutto P, Jadot S, Chimmanamada D, Zanda M, Wagner A, Mioskowski C, Massingham R, Guyaux M.
Abstract: The synthesis and biological evaluation of a novel family of M(3) muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.
CiteXplore: 16275087