Document Report Card

ID: ALA1147785

Journal: J Med Chem

Title: Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.

Authors: Micale N, Kozikowski AP, Ettari R, Grasso S, Zappalà M, Jeong JJ, Kumar A, Hanspal M, Chishti AH.

Abstract: The synthesis of a new class of peptidomimetics 1a-j, based on a 1,4-benzodiazepine scaffold and on a C-terminal aspartyl aldehyde building block, is described. Compounds 1a-j provided significant inhibitory activity against falcipains 2A and 2B (FP-2A and FP-2B), two cysteine proteases from Plasmodium falciparum.

CiteXplore: 16722625

DOI: 10.1021/jm060405f