Basic Information
ID: ALA1147873
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel analogues of dictyostatin.
Authors: Paterson I, Gardner NM, Poullennec KG, Wright AE.
Abstract: Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
CiteXplore: 17336522
DOI: 10.1016/j.bmcl.2007.02.031
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets