Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.
Basic Information
ID: ALA1147960
Journal: Eur J Med Chem
Title: Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.
Authors: Tan JH, Lu YJ, Huang ZS, Gu LQ, Wu JY.
Abstract: The DNA binding properties of three cation-substituted anthrapyrazole derivatives of emodin with calf thymus DNA were characterized by spectroscopic methods and the specific binding modes were elucidated. At low drug and high DNA concentrations, compound 1 with a mono-cationic amino side chain exhibited an intercalative binding mode, 2 with a much longer and more flexible di-cationic side chain exhibited an external binding mode, and 3 with a rigid di-cationic side chain exhibited both intercalative and external binding modes. The DNA binding mode of compounds was altered after structural modification. The molecular structure-DNA binding relationships found from this study may be useful for the design of anthrapyrazole derivatives with desired binding characteristics.
CiteXplore: 17408812
DOI: 10.1016/j.ejmech.2007.02.002
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