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ID: ALA1147968
Journal: Eur J Med Chem
Title: Novel lbeta-methylcarbapenems having cyclic sulfonamide moieties: synthesis and evaluation of in vitro antibacterial activity.
Authors: Kim SJ, Park HB, Lee JS, Jo NH, Yoo KH, Baek D, Kang BW, Cho JH, Oh CH.
Abstract: The synthesis of a new series of 1beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.
CiteXplore: 17418453