Document Report Card

ID: ALA1148076

Journal: J Nat Prod

Title: Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii.

Authors: Fuller RW, Cardellina JH, Cragg GM, Boyd MR.

Abstract: A characteristic pattern of differential cytotoxicity of extracts of Iberis amara seeds, predominantly toward renal tumor, brain tumor, and melanoma cell lines in the NCI human disease-oriented tumor screening panel, was traced to cucurbitacins E [1] and I [2]. This same differential cytotoxicity profile was detected in extracts of Begonia plebeja and Gonystylus keithii. Computer-assisted recognition of these profiles was followed by a rapid chemical fractionation, thus permitting the efficient dereplication of those extracts containing cucurbitacins B [3] and D [4], respectively. This is the first report of cucurbitacins from the genus Gonystylus.

CiteXplore: 7807128

DOI: 10.1021/np50112a015