Document Report Card

ID: ALA1148105

Journal: J Nat Prod

Title: Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.

Authors: Malmstrøm J, Christophersen C, Barrero AF, Oltra JE, Justicia J, Rosales A.

Abstract: From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.

CiteXplore: 11908979

DOI: 10.1021/np0103214