Total synthesis and bioactivity of some naturally occurring pterulones.

ID: ALA1148125

Journal: J Nat Prod

Title: Total synthesis and bioactivity of some naturally occurring pterulones.

Authors: Gruijters BW, van Veldhuizen A, Weijers CA, Wijnberg JB.

Abstract: The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorulaglutinis and Saccharomyces cerevisiae.

CiteXplore: 11975500

DOI: 10.1021/np010510m

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