Document Report Card

ID: ALA1148180

Journal: J Nat Prod

Title: The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from Pseudolarix kaempferi.

Authors: Chen GF, Li ZL, Pan DJ, Tang CM, He X, Xu GY, Chen K, Lee KH.

Abstract: Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharyngeal), A-549 (lung), and HCT-8 (colon), and against a murine leukemia cell line (P-388) with ED50 values of 0.49, 0.67, 0.73, and 0.79 micrograms/ml, respectively.

CiteXplore: 8377017

DOI: 10.1021/np50097a015