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ID: ALA1148225
Journal: Bioorg Med Chem Lett
Title: Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.
Authors: Allen S, Newhouse B, Anderson AS, Fauber B, Allen A, Chantry D, Eberhardt C, Odingo J, Burgess LE.
Abstract: Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening. Subsequent lead optimization efforts resulted in defined structure-activity relationships and the identification of potent antagonists (compounds 90 and 91) that inhibited the chemotaxis of Th2 T-cells in vitro.
CiteXplore: 15026036