Document Report Card
Basic Information
ID: ALA1148233
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of macrocyclic inhibitors of phosphatase cdc25B.
Authors: Bäurle S, Blume T, Günther J, Henschel D, Hillig RC, Husemann M, Mengel A, Parchmann C, Schmid E, Skuballa W.
Abstract: Based on molecular modeling studies, macrocyclic inhibitors of phosphatase cdc25B were synthetically derived from steroids. A preliminary SAR for this new template was elaborated. A series of compounds shows inhibition of cdc25B in the low micromolar range and good selectivity versus other phosphatases. The compounds did not show a significant antiproliferative effect in MaTu or HaCaT cells.
CiteXplore: 15026048