Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening.
Basic Information
ID: ALA1148254
Journal: Bioorg Med Chem Lett
Title: Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening.
Authors: Cheon HG, Lee CM, Kim BT, Hwang KJ.
Abstract: N-Ureido-quinoxalinedione derivatives have been discovered as leads for a novel series of dipeptidyl peptidase-IV (DPP-IV) inhibitors through high-throughput screening of our chemical library. A brief structure-activity relationship of the compounds was investigated. Among them, entry 5 showed the most potent inhibitory activity. The nitro group in quinoxaline moiety and the aromatic sulfonyl substituted ureido functional group seem to be important to increase the potency dramatically.
CiteXplore: 15109673
DOI: 10.1016/j.bmcl.2004.02.065
Patent ID: ┄