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ID: ALA1148509
Journal: Bioorg Med Chem Lett
Title: Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile.
Authors: Abel U, Simon W, Eckard P, Hansske FG.
Abstract: We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.
CiteXplore: 16621542