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ID: ALA1148516
Journal: Bioorg Med Chem Lett
Title: Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures.
Authors: Shimizu K, Kawase A, Haneishi T, Kato Y, Kinoshita K, Ohmori M, Furuta Y, Emura T, Kato N, Mitsui T, Yamaguchi K, Morita K, Sekiguchi N, Yamamoto T, Matsushita T, Shimaoka S, Sugita A, Morikawa K.
Abstract: Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2).
CiteXplore: 16630723