3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.

ID: ALA1148533

Journal: Bioorg Med Chem Lett

Title: 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.

Authors: Weide T, Arve L, Prinz H, Waldmann H, Kessler H.

Abstract: In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

CiteXplore: 16236508

DOI: 10.1016/j.bmcl.2005.09.051

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