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ID: ALA1148556
Journal: Bioorg Med Chem Lett
Title: Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.
Authors: Amori L, Serpi M, Marinozzi M, Costantino G, Diaz MG, Hermit MB, Thomsen C, Pellicciari R.
Abstract: Two novel constrained l-AP4 analogues, (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines (7) and (8), were synthesized and evaluated as mGluR ligands. Compound 7 showed to be a group III mGluRs agonist with micromolar activity.
CiteXplore: 16213710