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ID: ALA1148558
Journal: Bioorg Med Chem Lett
Title: Optimization of CCR4 antagonists: side-chain exploration.
Authors: Purandare AV, Wan H, Gao A, Somerville J, Burke C, Vaccaro W, Yang X, McIntyre KW, Poss MA.
Abstract: The design, synthesis, and activity of novel and selective small molecule antagonists of the CC chemokine receptor-4 (CCR4) are presented. Compound 8c was efficacious in a murine allergic inflammation model (ED(50) 30 mg/kg).
CiteXplore: 16236499