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ID: ALA1148560
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.
Authors: Suresh Babu K, Hari Babu T, Srinivas PV, Hara Kishore K, Murthy US, Rao JM.
Abstract: The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).
CiteXplore: 16213726