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ID: ALA1148567
Journal: Bioorg Med Chem Lett
Title: Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors.
Authors: Pinard E, Ceccarelli SM, Stalder H, Alberati D.
Abstract: Screening of the Roche compound library led to the identification of cis-N-(2-phenyl-cyclohexyl)-spiropiperidine 1 as structurally novel GlyT1 inhibitor. The SAR, which was developed in this series, resulted in the discovery of highly potent compounds displaying excellent selectivity against the GlyT2 isoform.
CiteXplore: 16246557