Document Report Card

ID: ALA1148589

Journal: J Med Chem

Title: Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

Authors: Somu RV, Boshoff H, Qiao C, Bennett EM, Barry CE, Aldrich CC.

Abstract: A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

CiteXplore: 16392788

DOI: 10.1021/jm051060o