Document Report Card

ID: ALA1148607

Journal: J Med Chem

Title: A minimalist design approach to antimicrobial agents based on a thionin template.

Authors: Vila-Perelló M, Tognon S, Sánchez-Vallet A, García-Olmedo F, Molina A, Andreu D.

Abstract: Numerous studies have been devoted to the stabilization of secondary structure elements to improve receptor-ligand recognition. We report a novel application of this principle to create new antimicrobial agents using the highly folded thionin from Pyrularia puberaas a template. Non-native disulfide bonds have been used to induce two short linear segments of the protein into an amphipathic helix. The resulting 13- and 9-residue peptides are significantly more active than their linear counterparts and have an activity similar to that of native thionin.

CiteXplore: 16420028

DOI: 10.1021/jm050882i