Document Report Card

ID: ALA1148611

Journal: J Med Chem

Title: Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.

Authors: Ma D, Jiang Y, Chen F, Gong LK, Ding K, Ding K, Xu Y, Wang R, Ge A, Ren J, Li J, Li J, Ye Q.

Abstract: The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of gamma-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC(50) values between 0.20 and 1.51 microuM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.

CiteXplore: 16420030

DOI: 10.1021/jm051101g