Rapid synthesis of triazole-modified resveratrol analogues via click chemistry.

ID: ALA1148612

Journal: J Med Chem

Title: Rapid synthesis of triazole-modified resveratrol analogues via click chemistry.

Authors: Pagliai F, Pirali T, Del Grosso E, Di Brisco R, Tron GC, Sorba G, Genazzani AA.

Abstract: Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency.

CiteXplore: 16420033

DOI: 10.1021/jm051118z

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