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ID: ALA1148659
Journal: Bioorg Med Chem Lett
Title: Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents.
Authors: Li J, Bertinato P, Cheng H, Cole BM, Bronk BS, Jaynes BH, Hickman A, Haven ML, Kolosko NL, Barry CJ, Manion TB.
Abstract: We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.
CiteXplore: 16529928