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ID: ALA1148661
Journal: Bioorg Med Chem Lett
Title: SAR studies: designing potent and selective LXR agonists.
Authors: Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD.
Abstract: Counterscreening compounds from a Merck PPAR program discovered lead 1, as a nanomolar LXR/PPAR dual agonist. SAR optimization developed a series of heterocyclic LXR agonists having excellent selectivity over all PPAR isoforms and possessing high LXR affinity and strong in vivo potency.
CiteXplore: 16529931